"The loss of reason, a sense of alienation from the commonsense world we all like to imagine we inhabit, the shattering emotional turmoil that seizes hold and won't let go--these are some of the traits we associate with madness. Today, mental disturbance is most commonly viewed through a medical lens, but societies have also sought to make sense of it through religion or the supernatural, or by constructing psychological or social explanations in...

Public perceptions of mental health issues have changed dramatically over the last fifteen years, and nowhere more than in the rampant overmedication of ordinary Americans. In 2006, 227 million antidepressant prescriptions were dispensed in the United States, more than any other class of medication; that year, the United States accounted for 66% of the global market. Here, psychiatrist Barber provides a context for this disturbing phenomenon. He explores...

"A history of American psychiatry-from jails to hospitals to the lab to the analyst's couch. For more than two hundred years, disturbances of the mind-the sorts of things that were once called "madness"-have been studied and treated by the medical profession. Mental illness, some insist, is a disease like any other, whose origins can be identified and from which one can be cured. But is this true? In this account of America's quest to understand and...

Gifty is a fifth year candidate in neuroscience at Stanford School of Medicine studying reward seeking behavior in mice and the neural circuits of depression and addiction. Her brother, Nana, was a gifted high school athlete who died of a heroin overdose after a knee injury left him hooked on OxyContin. Her suicidal mother is living in her bed. Gifty is determined to discover the scientific basis for the suffering she sees all around her. But even...

"On July 20, 2012 in Aurora, Colorado, a man in dark body armor and a gas mask entered a midnight premiere of The Dark Knight Rises with a tactical shotgun, a high-capacity assault rifle, and a sidearm. He threw a canister of tear gas into the crowd and began firing. Soon twelve were dead and fifty-eight were wounded; young children and pregnant women were among them. The man was found calmly waiting at his car. He was detained without resistance....