When former executive Jeffrey Wigand is fired by his employer, one of the largest tobacco companies in America, Wigand agrees to become a paid consultant for a story by veteran 60 minutes producer Lowell Bergman, regarding alleged unethical practices within the tobacco industry. But what begins as a temporary alliance leads to a lengthy battle for both men to save their reputations and more.

House is serving a prison sentence for driving his car into Cuddy's living room, and when his sentence ends early, he finds the Diagnostic Medicine Department has gone through a transition in his absence and he must deal with a new chain of command and personnel changes to his staff. Together, House and his new team take on the most baffling medical cases yet, and face challenges of both the mind and heart as this television phenomenon comes to a...