The story takes place in Yukon Territory, Canada, during the Klondike Gold Rush at the end of the 19th-century, and details a wild wolfdog's journey to domestication. White Fang is a companion novel to London's best-known work, The Call of the Wild.

Four stories set in the Klondike, including the classic adventures of an unusual dog, part St. Bernard, part Scotch shepherd, forcibly taken to the Klondike gold fields where he eventually becomes the leader of a wolf pack.

In these classic tales of the Yukon, a sled dog and a wolf struggle to suppress their wild instincts to serve their human masters.