Three angry independents are set to take on the most vicious gang of hijackers to ever run the highways.

A young Air Force veteran, Carrol Jo Hummer, starts a business as the owner-operator of a thirteen-speed, seven-and-one-half-ton diesel truck, which he dresses up and names The Blue Mule. With his bride, Jerri, he sets off to Tucson, Arizona, where his old friend Duane, the manager of a trucking company, gets him a job. But after Carrol Jo realizes he will be carrying illegal cargo and refuses the assignment, he's beaten by a band of gangsters working...

Philo Beddoe, a regular easy-going, beer-drinking truck driver and the toughest barroom brawler west of the Rockies, lives with a 165-pound orangutan named Clyde. When he finally falls in love, it's with a flighty singer who leads him on a crazy chase across the Southwest.

A man searches for his missing wife after his car breaks down in the middle of the desert.

Every which way but loose: Philo Beddoe, a regular easy-going, beer-drinking truck driver and the toughest barroom brawler west of the Rockies, lives with a 165-pound orangutan named Clyde. When he finally falls in love, it's with a flighty singer who leads him on a crazy chase across the Southwest. Any which way you can: Philo Beddoe faces his most dangerous challenge at the hands of an unbeaten bruiser from back East. There's big money at stake,...

Ex-G.I. Nick Garcos is a tyro trucker bent on satisfaction from the man responsible for crippling his father, a ruthless market operator by the name of Mike Figlia. Along the way, he is seduced by the siren Rica and drawn into the San Francisco produce racket, landing him in a web of treachery and heartbreak.