When Megan Murphy discovered a floppy-eared rabbit gnawing on the hem of her skirt, she meant to give its careless owner a piece of her mind, but Dr. Patrick Hunter was too attractive to stay mad at for long. Soon the two are making Thanksgiving dinner for their families.

Will Butterfield can't believe it. His 75–year–old mother, Holly, is drunk and threatening to jump off the roof. Again.

Holly and Fiona, another elderly relative, won't stop tormenting Will and his wife Elizabeth with their bizarre (though often amusing) antics. Between Will's worries about his bookstore, The Heart's Ease, and Elizabeth's troublesome high school students, dealing with "the crazies" has become just too much.