Having once led a life of comfort and self-indulgence, Jimmy, now known as Snowman, has survived an ecological disaster that has destroyed the world as we know it. As he struggles to function without everything he once knew, including time, Snowman reflects on the past, on his relationships with two characters named Oryx and Crake, and on the role of each individual in the destruction of the natural world.

"Heavily pregnant Alice and her partner Pete are done with the city. Alice is haunted by rumors of a skin-sealing epidemic starting to infect the urban population. She hopes their new remote mountain house will offer safety, a place to forget the nightmares and start their family. But the mountains and their people hold a different kind of danger. With their relationship under intolerable pressure, violence erupts and Alice is faced with the unthinkable...

One night in an isolated college town in the hills of Southern California, a first-year student stumbles into her dorm room, falls asleep, and doesn't wake up. She sleeps through the morning, into the evening. Her roommate, Mei, cannot rouse her. Neither can the paramedics, nor the perplexed doctors at the hospital. When a second girl falls asleep, and then a third, Mei finds herself thrust together with an eccentric classmate as panic takes hold...

Working at the local processing plant, Marcos is in the business of slaughtering humans-- though no one calls them that anymore. First an infectious virus made all animal meat poisonous to humans. Then governments initiated the "Transition." Now, eating "special meat" is legal. Then one day he is given a live specimen of the finest quality. Though aware that any form of personal contact is forbidden on pain of death, little by little Marcos starts...

In a future world baked dry by the sun and divided into those who live inside the wall and those who live outside it, sixteen-year-old midwife Gaia Stone is forced into a difficult choice when her parents are arrested and taken into the city.